@article{30535, author = {Singh AK and Bishai WR}, title = {Partners in Crime: Phenolic Glycolipids and Macrophages.}, abstract = {
Two recent articles advance our understanding of mycobacterial pathogenesis, revealing key roles for bacterially derived phenolic glycolipids (PGLs). In leprosy, Mycobacterium leprae PGL-1 uniquely subverts local macrophages to produce neurotoxic nitric oxide (NO), leading to nerve demyelination. In a related model, Mycobacterium marinum PGL stimulates the recruitment of growth-conducive monocytes to sites of initial infection as an early immune evasion strategy.
}, year = {2017}, journal = {Trends in molecular medicine}, issn = {1471-499X}, doi = {10.1016/j.molmed.2017.09.003}, language = {eng}, }