@article{30379,
  keywords = {leprosy, Histopathological diagnosis, Fite Faraco stain, disagreement, Clinical diagnosis, agreement},
  author = {Arunagirinathan M and Muniswamy V and Jeevirathinam S},
  title = {Clinical and Histopathological Correlation in Hansen{\textquoteright}s Disease},
  abstract = {<p><strong>BACKGROUND:\&nbsp;</strong>The\&nbsp; present\&nbsp; study\&nbsp; was\&nbsp; carried out\&nbsp; to\&nbsp; correlate\&nbsp; clinical\&nbsp; diagnosis\&nbsp; of\&nbsp; new\&nbsp; leprosy\&nbsp; cases\&nbsp; with\&nbsp; that\&nbsp; of\&nbsp; histopathological\&nbsp; diagnosis\&nbsp; of\&nbsp; skin\&nbsp; biopsies\&nbsp; stained\&nbsp; with\&nbsp; Haematoxylin\&nbsp; and\&nbsp; Eosin\&nbsp; followed\&nbsp; by\&nbsp; Fite\&nbsp; Faraco\&nbsp; stain.</p>

<p><strong>METHOD:\&nbsp;</strong>Skin\&nbsp; biopsies of\&nbsp; 70 newly\&nbsp; diagnosed\&nbsp; leprosy\&nbsp; patients\&nbsp; were\&nbsp; fixed\&nbsp; in\&nbsp; 10\% formalin\&nbsp; and\&nbsp; routine\&nbsp; histopathological\&nbsp; examination done\&nbsp; followed\&nbsp; by\&nbsp; special\&nbsp; stain ( Fite\&nbsp; Faraco )\&nbsp; to\&nbsp; evaluate\&nbsp; the\&nbsp; bacterial\&nbsp; index.\&nbsp;</p>

<p><strong>RESULTS:\&nbsp;</strong>From\&nbsp; this\&nbsp; study\&nbsp; it\&nbsp; was \&nbsp;observed\&nbsp; that,\&nbsp; the\&nbsp; commonest\&nbsp; age\&nbsp; group\&nbsp; affected\&nbsp; by\&nbsp; leprosy\&nbsp; was\&nbsp; 31\&nbsp; to\&nbsp; 50\&nbsp; years,\&nbsp; males\&nbsp; are\&nbsp; twice\&nbsp; more\&nbsp; commonly\&nbsp; affected\&nbsp; than\&nbsp; females ( M:F = 1.9 : 1 )\&nbsp; and\&nbsp; the\&nbsp; most\&nbsp; commonest\&nbsp; clinically\&nbsp; diagnosed\&nbsp; spectrum\&nbsp; was\&nbsp; Tuberculoid leprosy\&nbsp; ( TT ).\&nbsp; The\&nbsp; commonest\&nbsp; histopathologically\&nbsp; diagnosed\&nbsp; spectrum\&nbsp; was\&nbsp; Indeterminate\&nbsp; leprosy( IL ). It \&nbsp;was\&nbsp; observed\&nbsp; that\&nbsp; there\&nbsp; was\&nbsp; complete\&nbsp; agreement\&nbsp; between\&nbsp; clinical\&nbsp; diagnosis\&nbsp; and\&nbsp; histopathological\&nbsp; diagnosis\&nbsp; in\&nbsp; 62.85\%\&nbsp; cases\&nbsp; and\&nbsp; disagreement was\&nbsp; observed\&nbsp; in\&nbsp; 37.15\%\&nbsp; cases.</p>

<p><strong>CONCLUSION:\&nbsp;</strong>In\&nbsp; case\&nbsp; of\&nbsp; confirmed\&nbsp;\&nbsp; discrepancy,\&nbsp; the\&nbsp; more\&nbsp; advanced\&nbsp; findings ( ie.\&nbsp; towards\&nbsp; the\&nbsp; lepromatous\&nbsp; pole )\&nbsp; should\&nbsp; be\&nbsp; given\&nbsp; greater\&nbsp; weightage\&nbsp; and\&nbsp; the\&nbsp; case\&nbsp; is\&nbsp; to\&nbsp; be\&nbsp; classified\&nbsp; and\&nbsp; treated\&nbsp; accordingly.</p>
},
  year = {2017},
  journal = {Annals of pathology and laboratory medicine.},
  volume = {4},
  pages = {A454-A459},
  issn = {2394-6466},
  url = {http://www.pacificejournals.com/journal/index.php/apalm/article/download/1462/pdf_407},
  language = {eng},
}