@article{30359,
  keywords = {Proprioception, Polyneuropathy, Multibacillary, Mononeuritis multiplex, leprosy, Electrophysiology},
  author = {Sajid I},
  title = {Lepromatous Leprosy and associated proprioceptive loss},
  abstract = {<p><strong>Background: </strong>Leprosy presents commonly with mononeuritis multiplex, affecting mainly the exteroceptive sensations. Neuropathy with a significant afferent large fiber element is considered to be an uncommon manifestation of leprous neuropathy. Aims: To evaluate the clinical and neurophysiologic aspects of a sub set of patients with leprous neuropathy having clinical proprioceptive loss. <strong>Settings and Design:</strong> Prospective study of patients with a diagnosis of peripheral neuropathy secondary to leprosy having proprioceptive loss. <strong>Materials and Methods:</strong> Consecutive patients seen during a 2 year period (2004 and 2005) diagnosed to have leprous neuropathy with proprioceptive abnormalities on clinical examination were included. The diagnosis of leprosy was achieved by positive skin biopsy, split skin smears or nerve biopsy. Their clinical and electrophysiological characteristics were studied. Statistical methods: The results were analyzed using various tests of significance, including Pearson Chi-Square test. Values less than 0.05 were considered to be statistically significant. <strong>Results and Conclusions:</strong> We observed predominance (78.95%) of multibacillary forms of leprosy. Symmetrical neuropathies outnumbered mononeuritis multiplex (12:7). The pan sensory neuropathy had a mean duration of 24.32 months, but sometimes appeared early in the course of the disease. Areflexia and electrophysiological evidence of proximal affection was common, reflecting proximal spread of neuropathic process. Such patients have higher incidence of developing deformities and ulcerations and they represent a vulnerable sub set of patients with leprosy.</p>
},
  year = {2016},
  journal = {Journal of dental and medical sciences},
  volume = {15},
  pages = {38-41},
  issn = {2279-0861},
  url = {https://pdfs.semanticscholar.org/7a21/48912fca7536dc253e6cfe6380f38a1eb301.pdf},
  language = {eng},
}