@article{29916,
  keywords = {leprosy, Household contact, IDALLE L-ESAT 6, Phenolic Glycolipid-1},
  author = {Hadi MI and Keman S and Agusni I and Wahyuni CU},
  title = {The Correlation Between Subclinical Stage of Leprosy and Antibody Level of IDALLE L-ESAT 6 on Household Contact in Endemic Leprosy Area},
  abstract = {<p>Leprosy is an infectious disease caused by M. leprae. One of a high-risk group of leprosy is people who live at home together with the lepers. Since a long ago, it had been known that there was a certain subclinical stage in leprosy. In this case, the leper doesn{\textquoteright}t show the clinical symptoms of leprosy, but it can be found the antibody against the leprosy bacillus, especially Phenolic Glycolipid-1 in his/her blood serum. Moreover, this research aimed at analyzing the correlation between the occurrence of subclinical stage of leprosy and the antibody against protective epitopes of IDALLE L-ESAT 6, which was discovered by Kurdi et al. (2010) in a group of healthy nurse who had treated the lepers more than 10 years. This observational research utilized cross sectional approach. The total sample was 95 people of household contact in a house with the lepers at Brondong sub-district, Lamongan district, East Java, Indonesia. Subclinical stage of leprosy was measured based on titter of IgM anti PGL-1 by utilizing ELISA method. In addition, a level of protective antibody of IgG anti IDALLE L-ESAT 6 was also measured by utilizing ELISA method. The results showed that 48 samples were seropositive household contact PGL-1 (1286.6 {\textpm} 756.428 U / ml) and 47 samples were seronegative household contact PGL-1 (287, 06 {\textpm}152,084 U/ml). The mean of IgG anti IDALLE L-ESAT 6 at PGL-1 seropositive household contact was 344.80 U / ml, whereas, PGL-1 seronegative household contact was 508.09 U / ml. However, it was found that cut off of antibody anti IDALLE L-ESAT 6 was in 348 U/ml with 50\% percentile calculation. By applying simple logistic regression analysis, it was known that there was a correlation between the occurrence of subclinical stage of leprosy and the level of IDALLE L-ESAT 6, the higher antibody level toward the IDALLE L-ESAT 6, in household contact the higher protection against M. leprae. Therefore, it would not grow to be subclinical stage of leprosy.</p>
},
  year = {2017},
  journal = {Dama International Journal of Researchers},
  volume = {2},
  pages = {50-56},
  issn = {2343-6743},
  url = {http://www.damaacademia.com/issue/volume2/issue3/DIJR-M-011.pdf},
  language = {eng},
}