@article{29393,
  keywords = {Vaccines, Synthetic, Vaccines, Contraceptive, Vaccination, Recombinant Fusion Proteins, Pregnancy, Mice, Inbred BALB C, Mice, Humans, Female, Escherichia coli Proteins, Enterotoxins, DNA, Contraception, Immunologic, Chorionic Gonadotropin, beta Subunit, Human, Bacterial Toxins, Antibody Formation, Antibodies, Animals},
  author = {Nand KN and Gupta JC and Panda A and Jain S and Talwar G},
  title = {Priming with DNA Enhances Considerably the Immunogenicity of hCG β-LTB Vaccine.},
  abstract = {<p><strong>PROBLEM: </strong>Necessity to elicit antibody response above the protective threshold titres by sexually active women immunized to prevent pregnancy.</p>

<p><strong>METHOD OF STUDY: </strong>Recombinant hCGβ-LTB vaccine expressed as both DNA and protein. Balb C mice employed for testing immunogenicity.</p>

<p><strong>RESULTS: </strong>Necessity to give three primary injections of the vaccine to elicit proper antibody response. Immunization twice with DNA form of the vaccine at fortnightly interval followed by the protein elicits a distinctly higher antibody response than proteinic vaccine alone. Antibodies generated are bio-effective against hCG.</p>

<p><strong>CONCLUSION: </strong>Immunization with the DNA form of the recombinant hCGβ-LTB vaccine twice at fortnightly interval followed by the proteinic form of the vaccine induces distinctly higher antibody response.</p>
},
  year = {2015},
  journal = {American journal of reproductive immunology (New York, N.Y. : 1989)},
  volume = {74},
  pages = {302-8},
  issn = {1600-0897},
  doi = {10.1111/aji.12388},
  language = {eng},
}