@article{2785,
  keywords = {Animals, Cytokines, Disease Susceptibility, Female, leprosy, Macrophages, Peritoneal, Male, Mycobacterium leprae, Rats, Rats, Inbred F344, Rats, Inbred SHR, Rats, Nude},
  author = {Yogi Y and Endoh M and Banba T and Kobayashi M and Katoh H and Suzuki K and Nomaguchi H},
  title = {[Susceptibility to Mycobacterium leprae of congenic hypertensive nude rat (SHR/NCrj-rnu) and production of cytokine from the resident peritoneal macrophages].},
  abstract = {<p>We have established a congenic hypertensive nude rat strain, SHR/NCrj-rnu, carrying nude (rnu) and hypertension genes which was produced using females of the SHR/NCrj rat and males of the F344/NJcl nude rat by cross-intercross system for 12 generations. We demonstrated the susceptibility to M. leprae infection of SHR/NCrj-rnu rats as compared with F344/NJcl-rnu rats. SHR/NCrj-rnu rats were highly susceptible to M. leprae, and the SHR/NCrj-rnu rats of both sexes showed massive swelling of legs due to multiplication of M. leprae. However, F344/NJcl-rnu rats of both sexes revealed very poor susceptibility to M. leprae. There was a wide difference in the susceptibility to M. leprae between the SHR/NCrj-rnu and the F344/NJcl-rnu rats. We also examined the cytokine production. The resident peritoneal macrophages of SHR/NCrj-rnu rats produced IL-1 alpha, IL-6, IL-10 and TNF alpha, whereas those of F344/NJcl-rnu rats produced only TNF alpha.</p>},
  year = {2002},
  journal = {Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association},
  volume = {71},
  pages = {39-45},
  month = {2002 Feb},
  issn = {1342-3681},
  language = {jpn},
}