@article{2678,
  keywords = {Animals, Base Sequence, Drug Resistance, Microbial, Humans, Leprostatic Agents, leprosy, Mice, Molecular Sequence Data, Mycobacterium leprae, Oligonucleotide Probes, polymerase chain reaction, Predictive Value of Tests, Rifampin},
  author = {Honoré N and Roche P W and Grosset J H and Cole S T},
  title = {A method for rapid detection of rifampicin-resistant isolates of Mycobacterium leprae.},
  abstract = {<p>A genotypic method for predicting rifampicin resistance in Mycobacterium leprae has been developed and rigorously tested on mouse footpad-derived and clinical specimens. A series of immobilized oligonucleotide capture probes can discriminate between wild type and mutant rpoB alleles, and positive controls are available for the most frequent mutation affecting Ser425. Two different non-radioactive detection formats have been tested with comparable success in both an industrialized and a developing country. The standardized procedure could now be used in a prospective study of potential rifampicin resistance among multibacillary patients.</p>},
  year = {2001},
  journal = {Leprosy review},
  volume = {72},
  pages = {441-8},
  month = {2001 Dec},
  issn = {0305-7518},
  url = {http://leprev.ilsl.br/pdfs/2001/v72n4/pdf/v72n4a07.pdf},
  doi = {10.5935/0305-7518.20010052},
  language = {eng},
}