@article{26172,
  author = {Swathi M and Tagore R},
  title = {Study of Oxidative Stress in Different Forms of Leprosy.},
  abstract = {<p><strong>BACKGROUND: </strong>Leprosy is a chronic infectious disease caused by Mycobacterium leprae. India records the highest number of new leprosy cases in the world. Oxidative stress may play a significant role in leprosy.</p>

<p><strong>AIM: </strong>The aim of the study was to evaluate oxidative stress in various forms of leprosy and compared to healthy controls.</p>

<p><strong>MATERIALS AND METHODS: </strong>Seventy newly diagnosed, untreated leprosy patients were selected as cases and sixty healthy controls. Oxidative stress was evaluated by measuring serum malondialdehyde (MDA) level and superoxide dismutase (SOD) activity. Student{\textquoteright}s unpaired t-test and Anova (Analysis of Variance) test were used for analysis of data. P \&lt; 0.05 was considered as significant.</p>

<p><strong>RESULTS: </strong>There was a statistically significant increase in the mean values of serum MDA level, MDA/SOD and a decrease in serum SOD activity in cases when compared to controls and the values were significantly associated with increased duration, bacterial load and multibacillary type in leprosy.</p>

<p><strong>CONCLUSION: </strong>Our study suggests that there was oxidative stress in leprosy. This warrants antioxidant supplementation to prevent tissue injury.</p>
},
  year = {2015},
  journal = {Indian journal of dermatology},
  volume = {60},
  pages = {321},
  issn = {1998-3611},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458962/},
  doi = {10.4103/0019-5154.156426},
  language = {eng},
}