@article{2568, keywords = {Animals, Anti-Infective Agents, Antibiotics, Antitubercular, Base Sequence, DNA Primers, DNA, Bacterial, Drug Resistance, Microbial, Drug Resistance, Multiple, Genes, Bacterial, Humans, Leprostatic Agents, leprosy, Mice, Molecular Sequence Data, Mycobacterium leprae, Ofloxacin, Reverse Transcriptase Polymerase Chain Reaction, Rifampin}, author = {Maeda S and Matsuoka M and Nakata N and Kai M and Maeda Y and Hashimoto K and Kimura H and Kobayashi K and Kashiwabara Y}, title = {Multidrug resistant Mycobacterium leprae from patients with leprosy.}, abstract = {

Sequences of the folP1, rpoB, and gyrA genes were analyzed for 88 isolates of Mycobacterium leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines. Thirteen isolates (14.8%) showed representative mutations in more than two genes, suggesting the emergence of multidrug-resistant M. leprae.

}, year = {2001}, journal = {Antimicrobial agents and chemotherapy}, volume = {45}, pages = {3635-9}, month = {2001 Dec}, issn = {0066-4804}, doi = {10.1128/AAC.45.12.3635-3639.2001}, language = {eng}, }