@article{25314, keywords = {Pigmented purpuric dermatosis, Liver transplant, Fulminant hepatitis, Dapsone hypersensitivity syndrome}, author = {Garcia A and Yi N and Lee KB and Lee J and Choi YR and Suh S and You T and Lee K and Park JD and Kang HJ and Kim JG and Kang EK and Hong G and Suh K}, title = {Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: A case report.}, abstract = {

Dapsone is a sulfone-type drug used widely for different infectious, immune, and hypersensitivity disorders as an antibacterial treatment alone or in combination for leprosy and sometimes for infected skin lesions. DHS is a severe idiosyncratic adverse reaction with multi-organ involvement. However, acute necrotic hepatitis requiring an emergent LT is rare. Herein, we report a case of 12-yr-old girl who suffered from fulminant hepatitis and multi-organ failure due to DHS for PPD. She was saved by emergent LDLT. A high index of suspicion and rapid diagnosis are necessary not to miss this potentially lethal but rare disease.

}, year = {2014}, journal = {Pediatric transplantation}, issn = {1399-3046}, doi = {10.1111/petr.12343}, language = {eng}, }