@article{25837,
  keywords = {leprosy, Immune response, Hansen disease},
  author = {Tomimori J and Albuquerque RG and Okazaki KM and Hirotsu C and Tufik S and Andersen ML},
  title = {Sleep, Hansen{\textquoteright}s disease and the immune system {\textendash} a not so harmonic triad.},
  abstract = {<div>
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<p>Hansen{\textquoteright}s disease is one of the oldest skin diseases in the world characterized by a spectrum of clinical manifestations that are associated with stigmatization and poor quality of life. It is also considered a model disease for investigating the human immune system because of its association with immune reactions, which are thought to be a reflection of the host{\textquoteright}s immunological response, promoting intense cellular activity or humoral secretion. This relationship between the cellular and microbial components of skin and their regulation by local immune responses may be modulated by a currently neglected behavior: sleep. Recent studies have demonstrated that sleep deprivation may aggravate the progression of chronic dermatological diseases, which in turn can lead to a non-restorative sleep pattern. Indeed, sleep is essential for immune and skin integrity. Thus, we propose here a hypothesis linking Hansen{\textquoteright}s disease, sleep and immunity in a bidirectional relationship. Hansen{\textquoteright}s disease patients may demonstrate a worse sleep quality than the general population through the modulation of immunological environment; and sleep restriction, a hallmark of modern society, being a possible predictor of the disease progression.</p>
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  year = {2015},
  journal = {Medical Hypotheses},
  issn = {03069877},
  doi = {10.1016/j.mehy.2015.01.045},
  language = {eng},
}