@article{24591,
  keywords = {leprosy, Cellulair dammage, Brazil, Antioxidants},
  author = {Schalcher TR and Vieira JLF and Salgado CG and Borges RDS and Monteiro MC},
  title = {Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients.},
  abstract = {Introduction The immune response caused by Mycobacterium leprae is a risk factor for the development of oxidative stress (OS) in leprosy patients. This study aimed to assess OS in leprosy patients before the use of a multidrug therapy. Methods We evaluated the nitric oxide (NO) concentration; antioxidant capacity; levels of malondialdehyde, methemoglobin and reduced glutathione; and the activity of catalase and superoxide dismutase (SOD) in leprosy patients. Results We observed lower SOD activity in these leprosy patients; however, the NO levels and antioxidant capacity were increased. Conclusions The infectious process in response to M. leprae could primarily be responsible for the OS observed in these patients.},
  year = {2013},
  journal = {Revista da Sociedade Brasileira de Medicina Tropical},
  volume = {46},
  pages = {645-649},
  month = {2013 Sept-Oct},
  issn = {1678-9849},
  doi = {10.1590/0037-8682-1506-2013},
  language = {eng},
}