@article{24546,
  keywords = {leprosy, Histopathology, Immunology, Mexico},
  author = {Bravo T C},
  title = {New observations on the polar spectrum of human leprosy},
  abstract = {Leprosy is a chronic granulomatous infection of the skin and peripherial nerves, caused by Mycobacterium leprae. 
Leprosy clinical diagnosis should be considered whenever skin lesions and sensory loss occur. Recent immunologic 
research, classic bacteriological methods and histopathology, molecular bacteriology and the Ridley-Jopling 
(RJ) classifi cation which recognized clinical-types not as separate entities, but merely segments of a wide spectrum
ranging from purely localized, hyperergic, tuberculoid (TT) pole, trough the borderline (B) types, to the generalized, 
anergic lepromatous (LL) pole. Reactive episodes continue to be a serious complication, but the availability of 
thalidomide and clofazimine to control erythema nodosum leprosum, has much improved the prognosis. This review 
summarises recent advances in understanding the clinical features and pathogenesis of the disease.},
  year = {2013},
  volume = {60},
  pages = {205-223},
  url = {http://www.medigraphic.com/pdfs/patol/pt-2013/pt134b.pdf},
  language = {eng},
}