@article{24264, keywords = {Systematic review, Neuropathy, leprosy, diagnosis}, author = {Garbino JA and Marques Jr W and Barreto J and Heise CO and Rodrigues MMJ and Antunes S and Soares CT and Floriano MC and Nery JA and Bianconcini Trindade MA and Carvalho NB and Andrada NC and Barreira AA and Cunha Lopes Virmond M}, title = {Primary neural leprosy : systematic review}, abstract = {

The authors proposed a systematic review on the current concepts of primary neural leprosy by consulting the following online databases: MEDLINE, Lilacs/SciELO, and Embase. Selected studies were classified based on the degree of recommendation and levels of scientific evidence according to the “Oxford Centre for Evidence-based Medicine”. The following aspects were reviewed: cutaneous clinical and laboratorial investigations, i.e. skin clinical exam, smears, and biopsy, and Mitsuda's reaction; neurological investigation (anamnesis, electromyography and nerve biopsy); serological investigation and molecular testing, i.e. serological testing for the detection of the phenolic glycolipid 1 (PGL-I) and the polymerase chain reaction (PCR); and treatment (classification criteria for the definition of specific treatment, steroid treatment, and cure criteria).

}, year = {2013}, journal = {Arquivos de Neuro-Psiquiatria}, volume = {71}, url = {http://www.scielo.br/pdf/anp/v71n6/0004-282X-anp-71-06-397.pdf}, doi = {10.1590/0004-282X20130046}, language = {eng}, }