@article{23490,
  keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Child, Colombia, Endemic Diseases, Ethnic Groups, European Continental Ancestry Group, Female, Gene Frequency, Genetic Predisposition to Disease, genotype, Haplotypes, Humans, Interleukin-10, leprosy, Male, Middle Aged, Mycobacterium leprae, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Young Adult},
  author = {Cardona-Castro N and Sánchez-Jiménez M and Rojas W and Bedoya-Berrío G},
  title = {IL-10 gene promoter polymorphisms and leprosy in a Colombian population sample.},
  abstract = {<p><b>INTRODUCTION: </b>Polymorphisms in promoters of genes code for cytokines that affect transcription levels. Several have been associated with leprosy patients that have functional and clinical implications.</p><p><b>OBJECTIVE: </b>Polymorphisms in the promoter of the IL10 gene of leprosy patients will be compared frequencies in normal population.</p><p><b>MATERIALS AND METHODS: </b>SNPs (single nucleotide polymorphism) -1082 A/G (rs1800896), -819C/T (rs1800871), and -592A/C (rs1800872) were identified in 100 leprosy patients and in a control group of 100 volunteers from a leprosy endemic region of Colombia.</p><p><b>RESULTS: </b>The genotypes C/C and C/T in the SNP -819 were associated together with leprosy (OR=4.34, p<0.001).Similarly, the genotypes C/C and C/A in the -592 SNP showed an association (OR=4.3, p<0.001). The haplotypes -819C-519C and -1082A-819C-592C showed significant association (OR=4.34, p<0.001 and OR=6.25, p<0.001) respectively. These haplotypes in homozygosis conditions were also associated with leprosy: -819C-519C/-819C-519C (OR=4.34, p<0.001), -1082A -819C-592C/-1082A -819C-592C (OR=1.90, p=0.04). The SNP -1082 was not associated with leprosy in this population.</p><p><b>CONCLUSIONS: </b>The haplotypes associated with leprosy, -1082A-819C-592C/-1082A-819C-592C, have been reported as low producers of IL-10. Functionally, the low production of IL-10 may have immune response consequences and clinical implications. Additional haplotypes of IL-10 have been reported as markers for leprosy susceptibility or resistance in other ethnic populations. This suggests that differences in distribution of diverse IL-10 gene polymorphisms among ethnic groups may indicate important gene-disease associations.</p>},
  year = {2012},
  journal = {Biomedica : revista del Instituto Nacional de Salud},
  volume = {32},
  pages = {71-6},
  month = {2012 Jan-Mar},
  issn = {0120-4157},
  doi = {10.1590/S0120-41572012000100009},
  language = {eng},
}