@article{2331, keywords = {Adenosine Triphosphate, Animals, Foot, Humans, Leprostatic Agents, leprosy, Luminescent Measurements, Mice, Mycobacterium leprae, Treatment Outcome}, author = {Gupta U D and Katoch K and Singh H B and Natrajan M and Sharma V D and Katoch V M}, title = {Assessment of viability by normal mouse foot-pad and bacillary ATP bioluminescence assay in multibacillary cases treated with an MDT regimen using conventional as well as newer drugs like minocycline and ofloxacin.}, abstract = {

The therapeutic effect of a drug regimen of conventional drugs as well as newer drugs like ofloxacin and minocycline in smear-positive multibacillary (MB) leprosy cases was assessed by mouse foot-pad and ATP bioluminiscence methods. Biopsies were taken before starting treatment and after one year of treatment. They were processed for viability assessment by normal mouse foot-pad inoculation and bacillary ATP assay techniques. The test regimen was quite effective in its anti-bacterial effect as it was found to result in loss of bacillary viability in all the cases, as assessed by both methods.

}, year = {2000}, journal = {Indian journal of leprosy}, volume = {72}, pages = {437-42}, month = {2000 Oct-Dec}, issn = {0254-9395}, language = {eng}, }