@article{23139,
  keywords = {Asian Continental Ancestry Group, Crohn Disease, Family, Gene Expression Regulation, Genetic Predisposition to Disease, genotype, Humans, leprosy, Nod2 Signaling Adaptor Protein, Polymorphism, Single Nucleotide, Signal Transduction, Vietnam},
  author = {Grant A and Alter A and Huong NT and Orlova M and Van Thuc N and Ba NN and Thai VH and Abel L and Schurr E and Alcaïs A},
  title = {Crohn's disease susceptibility genes are associated with leprosy in the Vietnamese population.},
  abstract = {<p>A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease susceptibility loci. Here, we studied these 16 SNPs as potential leprosy susceptibility factors in 474 Vietnamese leprosy simplex families. We replicated SNPs at HLA-DR-DQ, RIPK2, CCDC122-LACC1, and NOD2 as leprosy susceptibility factors in Vietnam. These results validated the striking overlap in the genetic control of Crohn's disease and leprosy.</p>},
  year = {2012},
  journal = {The Journal of infectious diseases},
  volume = {206},
  pages = {1763-7},
  month = {2012 Dec 01},
  issn = {1537-6613},
  doi = {10.1093/infdis/jis588},
  language = {eng},
}