@article{2301,
  keywords = {Animals, Antigens, Bacterial, BCG Vaccine, Base Sequence, DNA Primers, leprosy, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mycobacterium bovis, Mycobacterium leprae, Plasmids, Spleen, Vaccines, Synthetic},
  author = {Ohara N and Matsuoka M and Nomaguchi H and Naito M and Yamada T},
  title = {Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates.},
  abstract = {<p>The components of Ag85 (Ag85A, Ag85B, and Ag85C) are putative protective antigen candidates against mycobacterial infection. A recombinant Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) over-producing Ag85A, Ag85B, and MPB51 (rBCG/BA51) was constructed. rBCG/BA51 could secrete these antigens at levels more than five times higher than parental BCG. Immunization of C57BL/6 and BALB/c mice with this rBCG reduced the multiplication of Mycobacterium leprae in the foot pads of both strains of mice. The inhibition by rBCG/BA51 was more evident than that by parental BCG.</p>},
  year = {2001},
  journal = {Vaccine},
  volume = {19},
  pages = {1906-10},
  month = {2001 Feb 28},
  issn = {0264-410X},
  doi = {10.1016/s0264-410x(00)00439-4},
  language = {eng},
}