@article{2284, keywords = {Autoimmunity, Humans, leprosy, Melanocytes, Melanoma, Skin, Symbiosis, Vitiligo}, author = {Das P K and Wijngaard R M and Wankowicz-Kalinska A and Le Poole I C}, title = {A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo.}, abstract = {
Vitiligo is a skin disease in which melanocytes (MCs) are eradicated from lesional epidermis, resulting in disfiguring loss of pigment. MCs are destroyed by MC-reactive T cells, as well as other non-immune and immune components. Similarities exist between the autoimmunity observed in vitiligo and the tumour immunity observed in melanoma immuno-surveillance. An analysis of these mechanisms might lead to the development of new therapies for both vitiligo and melanoma.
}, year = {2001}, journal = {Trends in immunology}, volume = {22}, pages = {130-6}, month = {2001 Mar}, issn = {1471-4906}, language = {eng}, }