@article{22681,
  keywords = {Adult, Apoptosis, Caspase 3, Female, Humans, leprosy, Male, Middle Aged, Mycobacterium leprae, Skin, Transforming Growth Factor beta},
  author = {Quaresma JAS and Almeida FAC and Aarão TLS and Soares LPMA and Nunes Magno IM and Fuzii HT and Libonati RMF and Xavier MB and Pagliari C and Duarte MIS},
  title = {Transforming growth factor β and apoptosis in leprosy skin lesions: possible relationship with the control of the tissue immune response in the Mycobacterium leprae infection.},
  abstract = {<p>The course of leprosy depends of the host immune response which ranges from the lepromatous pole (LL) to the tuberculoid pole (TT). A comparative study was conducted in 60 patients with the LL and TT. The results showed a mean expression of TGF-β of 339 ± 99.4 cells/field for TT and of 519.2 ± 68.2 cells/field for LL. Frequency of apoptosis was 6.3 ± 1.8 in TT and 14.0 ± 6.1 in LL. A correlation (p = 0.0251) between TGF-β and caspase-3 in the LL was found. This finding indicates a role of TGF-β and apoptosis in the immune response in leprosy.</p>},
  year = {2012},
  journal = {Microbes and infection},
  volume = {14},
  pages = {696-701},
  month = {2012 Aug},
  publisher = {Elsevier},
  address = {Paris; New York},
  issn = {1769-714X},
  doi = {10.1016/j.micinf.2012.02.010},
  language = {eng},
}