@article{23139,
  keywords = {Asian Continental Ancestry Group, Crohn Disease, Family, Gene Expression Regulation, Genetic Predisposition to Disease, genotype, Humans, leprosy, Nod2 Signaling Adaptor Protein, Polymorphism, Single Nucleotide, Signal Transduction, Vietnam},
  author = {Abel L and Alca{\"\i}s A and Schurr E and Van Thuc N and Thai VH and Huong NT and Ba NN and Alter A and Orlova M and Grant A},
  title = {Crohn{\textquoteright}s disease susceptibility genes are associated with leprosy in the Vietnamese population.},
  abstract = {<p>A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn{\textquoteright}s disease susceptibility loci. Here, we studied these 16 SNPs as potential leprosy susceptibility factors in 474 Vietnamese leprosy simplex families. We replicated SNPs at HLA-DR-DQ, RIPK2, CCDC122-LACC1, and NOD2 as leprosy susceptibility factors in Vietnam. These results validated the striking overlap in the genetic control of Crohn{\textquoteright}s disease and leprosy.</p>},
  year = {2012},
  journal = {The Journal of infectious diseases},
  volume = {206},
  pages = {1763-7},
  month = {2012 Dec 01},
  issn = {1537-6613},
  doi = {10.1093/infdis/jis588},
  language = {eng},
}