@article{22460, keywords = {Adult, Case-Control Studies, Female, Gene Frequency, Genetic Association Studies, Genetic Carrier Screening, Genetic Predisposition to Disease, Genetic Testing, Genotyping Techniques, Heterozygote, Humans, India, leprosy, Male, Middle Aged, Mycobacterium, Nod2 Signaling Adaptor Protein, Odds Ratio, Polymorphism, Single Nucleotide, Tuberculosis, Young Adult}, author = {Singh V and Gaur R and Mittal M and Biswas S K and Das R and Girdhar B K and Bajaj B and Katoch V M and Kumar A and Mohanty K K}, title = {Absence of nucleotide-binding oligomerization domain-containing protein 2 variants in patients with leprosy and tuberculosis.}, abstract = {

Crohn's disease-associated NOD 2 variants (Arg702Trp and 3020insC) were found to be monomorphic (wild), and 7 subjects were heterozygous for Gly908Arg SNP in 263 patients with tuberculosis, 260 patients with leprosy and 270 healthy controls residing in northern Indian states. This is the first report to suggest the minimal role of these variants in susceptibility/resistance to TB and leprosy in this population.

}, year = {2012}, journal = {International journal of immunogenetics}, volume = {39}, pages = {353-6}, month = {2012 Aug}, publisher = {Blackwell Publishing Ltd.}, address = {Oxford}, issn = {1744-313X}, doi = {10.1111/j.1744-313X.2012.01085.x}, language = {eng}, }