@article{22252,
  keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Alleles, Brazil, Case-Control Studies, Female, Gene Frequency, Genetic Predisposition to Disease, genotype, Histocompatibility Antigens Class I, Humans, leprosy, Male, Middle Aged, Young Adult},
  author = {Franceschi DSA and Tsuneto LT and Mazini PS and Sacramento WS and Reis PG and Rudnick CCC and Clementino SL and Sell AM and Visentainer JEL},
  title = {Class-I human leukocyte alleles in leprosy patients from Southern Brazil.},
  abstract = {<p><b>INTRODUCTION: </b>The present study was designed to investigate a possible role of HLA (histocompatibility leucocyte antigen) class-I alleles (HLA-A, -B, and -C) in leprosy patients from Southern Brazil.</p><p><b>METHODS: </b>Two hundred and twenty-five patients with leprosy and 450 individuals for the control group were involved in this research. HLA genotyping was performed through PCR-SSO protocols (One Lambda, USA); the frequency of these alleles was calculated in each group by direct counting, and the frequencies were then compared.</p><p><b>RESULTS: </b>There was an association between HLA-A*11 (6.9% vs 4.1%, p=0.0345, OR=1.72, 95% CI=1.05-2.81), HLA-B*38 (2.7% vs. 1.1%, p=0.0402, OR=2.44, 95% CI=1.05-5.69), HLA-C*12 (9.4% vs. 5.4%, p=0.01, OR=1.82, 95% CI=1.17-2.82), and HLA-C*16 (3.1% vs. 6.5%, p=0.0124, OR=0.47, 95% CI=0.26-0.85) and leprosy per se. In addition, HLA-B*35, HLA-C*04, and HLA-C*07 frequencies were different between lepromatous (LL) and tuberculoid (TT) patients. However, after adjusting for the number of alleles compared, Pc values became nonsignificant.</p><p><b>CONCLUSIONS: </b>Although our results do not support the previous findings that HLA class-I alleles play a role in leprosy pathogenesis, we suggest new studies because of the importance of the association between the HLA and KIR in the innate immune response to leprosy.</p>},
  year = {2011},
  journal = {Revista da Sociedade Brasileira de Medicina Tropical},
  volume = {44},
  pages = {616-20},
  month = {2011 Oct},
  publisher = {Scielo},
  address = {Rio de Janeiro},
  issn = {1678-9849},
  url = {http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000500018&nrm=iso},
  doi = {10.1590/s0037-86822011000500018},
  language = {eng},
}