@article{22216,
  keywords = {Bacterial Proteins, Dapsone, Humans, India, Leprostatic Agents, leprosy, Molecular Epidemiology, Mutation, Mycobacterium leprae, Philippines, Rifampin},
  author = {Li W and Sakamuri R and Lyons DE and Orcullo FM and Shinde V and Dela Pena EL and Maghanoy AA and Mallari I and Tan E and Nath I and Brennan PJ and Balagon M and Vissa V},
  title = {Transmission of dapsone-resistant leprosy detected by molecular epidemiological approaches.},
  abstract = {<p>Drug resistance surveillance identified six untreated leprosy patients in the Philippines with Mycobacterium leprae folP1 mutations which confer dapsone resistance. Five patients share a village of residence; four who carried the mutation, Thr53Val, were also linked by M. leprae variable-number tandem repeat (VNTR) strain types. In India, folP1 mutations were detected in two relapse patients with a history of dapsone treatment. Mutations were not found in the rifampin target gene rpoB. These findings indicate that dapsone resistance is being transmitted.</p>},
  year = {2011},
  journal = {Antimicrobial agents and chemotherapy},
  volume = {55},
  pages = {5384-7},
  month = {2011 Nov},
  publisher = { American Society for Microbiology},
  address = {Washington},
  issn = {1098-6596},
  doi = {10.1128/AAC.05236-11},
  language = {eng},
}