@article{21887,
  keywords = {Adolescent, Adult, Aged, Child, Child, Preschool, Gene Frequency, Genetic Predisposition to Disease, genotype, Histocompatibility Antigens Class I, Humans, India, Infant, leprosy, Middle Aged, Polymorphism, Single Nucleotide, Vietnam, Young Adult},
  author = {Alter A and Huong NT and Singh M and Orlova M and Van Thuc N and Katoch K and Gao X and Thai VH and Ba NN and Carrington M and Abel L and Mehra N and Alcaïs A and Schurr E},
  title = {Human leukocyte antigen class I region single-nucleotide polymorphisms are associated with leprosy susceptibility in Vietnam and India.},
  abstract = {<p>Experimental evidence suggested the existence of unidentified leprosy susceptibility loci in the human leukocyte antigen (HLA) complex. To identify such genetic risk factors, a high-density association scan of a 1.9-mega-base (Mb) region in the HLA complex was performed. Among 682 single-nucleotide polymorphisms (SNPs), 59 were associated with leprosy (P <.01) in 198 Vietnamese single-case leprosy families. Genotyping of these SNPs in an independent sample of 292 Vietnamese single-case leprosy families replicated the association of 12 SNPs (P <.01). Multivariate analysis of these 12 SNPs showed that the association information could be captured by 2 intergenic HLA class I region SNPs (P = 9.4 × 10⁻⁹)-rs2394885 and rs2922997 (marginal multivariate P = 2.1 × 10⁻⁷ and P = .0016, respectively). SNP rs2394885 tagged the HLA-C*15:05 allele in the Vietnamese population. The identical associations were validated in a third sample of 364 patients with leprosy and 371 control subjects from North India. These results implicated class I alleles in leprosy pathogenesis.</p>},
  year = {2011},
  journal = {The Journal of infectious diseases},
  volume = {203},
  pages = {1274-81},
  month = {2011 May 01},
  issn = {1537-6613},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069725/pdf/jir024.pdf},
  doi = {10.1093/infdis/jir024},
  language = {eng},
}