@article{21694,
  keywords = {Adolescent, Adult, Aged, Child, Cohort Studies, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Incidence, India, Leprostatic Agents, Leprosy, Multibacillary, Male, Middle Aged, Ocular Hypotension, Prevalence, Risk Factors, Young Adult},
  author = {Daniel E and Rao P S S and ffytche T J and Courtright P},
  title = {Ocular hypotension and hypotony in multibacillary leprosy patients; at diagnosis, during and after completion of multidrug therapy.},
  abstract = {<p>The prevalence and incidence of ocular hypotony (IOP < 7 mm Hg) and factors associated with them were determined in a Leprosy Referral Centre at Tamilnadu, India. Applanation intraocular pressures were measured every six months in a cohort of newly diagnosed multibacillary (MB) leprosy patients who were followed-up during the two year period of multidrug therapy (MDT) and for five years thereafter. Transient hypotony was present in two patients at the time of diagnosis, in 3 patients during MDT and in 9 patients after MDT with a cumulative prevalence of 4.65%. Transient ocular hypotension was present in 24 patients (8%) at disease diagnosis. 25 patients developed hypotension during MDT that was associated with trichiasis (HR 8.83 95% CI 2.06, 37.78 p = 0.003) and flare or/and cells (HR 4.60 95% CI 1.08, 19.64 p = 0.039). 29 patients developed ocular hypotension after MDT that was associated with punctate keratitis and uveal involvement. In general, MB leprosy patients with hypotension had a mean IOP of 12.60 mm Hg which differed significantly (p < 0.0001) from the mean IOP of 14.9 mm Hg in those who did not have hypotension. Transient hypotension and hypotony in MB leprosy patients are associated with signs of intraocular inflammation.</p>},
  year = {2010},
  journal = {Indian journal of leprosy},
  volume = {82},
  pages = {181-8},
  month = {2010 Oct-Dec},
  issn = {0254-9395},
  url = {http://www.ijl.org.in/archives/oct-dec-2010/Art1(Ebenezer%20Daniel%20et%20al)181-188.pdf},
  doi = {10.1002/gps.2707},
  language = {eng},
}