@article{21612,
  keywords = {Adolescent, Adult, Dinitrochlorobenzene, Disease Susceptibility, Female, Humans, Indicators and Reagents, Leprosy, lepromatous, Leprosy, Tuberculoid, Male, Middle Aged, Phenotype, Radiation Tolerance, Risk Factors, Ultraviolet Rays, Young Adult},
  author = {Rodrigues MM and Ximenes RAA and Dantas MMS and Batista TD and Freire AL},
  title = {UVB susceptibility as a risk factor to the development of lepromatous leprosy.},
  abstract = {<p><b>BACKGROUNDS: </b>Ultraviolet radiation B (UVRB) is the most important environmental factor capable of altering the immune function of human skin.</p><p><b>OBJECTIVE: </b>To evaluate the association of the phenotypes of susceptibility or resistance to ultraviolet radiation B (UVRB) and the polar forms of leprosy.</p><p><b>MATERIAL AND METHODS: </b>We evaluated 38 patients with lepromatous leprosy (LL) and 87 patients with tuberculoid (TT) leprosy, according to the classification by Ridley and Jopling (1966). All the patients were submitted to a test to determine the phenotypes of susceptibility or resistance to UVRB through the application of a 2% dinitrochlorobenzene (DNCB) disc to a previously irradiated area with twice the minimal erythema dose (MED). After 21 days, a similar disc soaked in 0.05% DNCB was applied to the scapular area (unexposed to UVRB) to check for sensitiveness, with reading of the results after 48 hours. The patients that showed a positive reaction to DNCB were considered resistant (UVB-R) and those who did not show any reaction were considered susceptible (UVB-S).</p><p><b>RESULTS: </b>The frequency of UVB-S individuals was 63.2% (24 patients) in the LL group and 34.4% (30 patients) in the TT group (OR=3.26; IC=1.36 - 7.87; x(2)=7.73; p=0.005).</p><p><b>CONCLUSION: </b>Our results suggest that UVB-susceptibility is a risk factor to the development of lepromatous leprosy (LL).</p>},
  year = {2010},
  journal = {Anais brasileiros de dermatologia},
  volume = {85},
  pages = {839-42},
  month = {2010 Nov-Dec},
  issn = {1806-4841},
  url = {http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962010000600009&lng=en&nrm=iso&tlng=en},
  doi = {10.1590/s0365-05962010000600009},
  language = {eng},
}