@article{2160,
  keywords = {Animals, Antibodies, Bacterial, Antigens, Bacterial, Disease Models, Animal, Female, Humans, Hypersensitivity, Delayed, Immunity, Cellular, Immunoelectrophoresis, Two-Dimensional, leprosy, Mice, Mice, Inbred C3H, Mice, Inbred C57BL, Mycobacterium lepraemurium},
  author = {Closs O and Kronvall G},
  title = {Experimental murine leprosy. IX. Antibodies against Mycobacterium lepraemurium in C3H and C57BL mice with murine leprosy and in patients with lepromatous leprosy.},
  abstract = {<p>Sera from C3H and C57BL mice infected with Mycobacterium lepraemurium (MLM) and from human leprosy patients were examined for antibodies against MLM by a crossed immunoelectrophoresis (CIE) technique. Altogether antibodies against six or seven MLM antigens were found in the mouse sera. After a small inoculum of MLM, C3H mice produced more antibodies than C57BL mice. After a large inoculum both strains produced about the same amount of antibodies but showed qualitative differences in their response patterns. A serum pool from patients with lepromatous leprosy contained antibodies against six MLM antigens; five of these were identical with the antigens against which antibodies were found in infected mice. C57BL mice that had lost their delayed-type hypersensitivity to MLM during the course of a disseminated infection showed a fairly strong antibody response to three antigens and a weak response to three others. Since almost the same spectrum of antibodies, although in lower titres, could be demonstrated in C57BL mice with intact delayed-type hypersensitivity to the bacilli, these antibodies did not seem to interfere with the expression of cell-mediated immunity.</p>},
  year = {1975},
  journal = {Scandinavian journal of immunology},
  volume = {4},
  pages = {735-40},
  month = {1975},
  issn = {0300-9475},
  doi = {10.1111/j.1365-3083.1975.tb02681.x},
  language = {eng},
}