@article{1952, keywords = {Adult, B-Lymphocytes, Female, Humans, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, leprosy, Lymphocyte Activation, Male, Middle Aged, T-Lymphocytes}, author = {Barnetson R and Barnetson A and Pearson J M and Kronvall G}, title = {Does nonspecific T-lymphocyte stimulation of B lymphocytes occur during reversal reaction in borderline leprosy?}, abstract = {
Serum immunoglobulins G, A, and M were estimated in 14 patients with border-line cases of leprosy at commencement of treatment and subsequently when they developed 'reversal reaction'. There was a significant increase in all immunoglobulin levels during the reaction, with a subsequent fall; the postreaction values for IgG and IgA were below the base-line figures. Additonal investigations in six patients indicated that the rise was a nonspecific one, not brought about by an increase in antimycobacterial antibodies. It seems likely that the rise in immunoglobulins during reaction is due to nonspecific T-lymphocyte stimulation of B lymphocytes.
}, year = {1976}, journal = {Scandinavian journal of immunology}, volume = {5}, pages = {287-91}, month = {1976}, issn = {0300-9475}, doi = {10.1111/j.1365-3083.1976.tb00280.x}, language = {eng}, }