@article{1931,
  keywords = {Antigen Presentation, Antigens, Antigens, Bacterial, Antigens, CD1, Antigens, Surface, CD4 Antigens, CD4-Positive T-Lymphocytes, Cell Membrane, Cells, Cultured, Glycolipids, Humans, Lectins, C-Type, leprosy, Lipopolysaccharides, Mycobacterium leprae, Mycolic Acids, NK Cell Lectin-Like Receptor Subfamily B, Peptides, Protein Biosynthesis, Proteins, Receptors, Immunologic, T-Lymphocyte Subsets},
  author = {Sieling P A and Ochoa M T and Jullien D and Leslie D S and Sabet S and Rosat J P and Burdick A E and Rea T H and Brenner M B and Porcelli S A and Modlin R L},
  title = {Evidence for human CD4+ T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions.},
  abstract = {<p>Both the CD4-CD8- (double negative) and CD4-CD8+ T cell lineages have been shown to contain T cells which recognize microbial lipid and glycolipid Ags in the context of human CD1 molecules. To determine whether T cells expressing the CD4 coreceptor could recognize Ag in the context of CD1, we derived CD4+ T cell lines from the lesions of leprosy patients. We identified three CD4+ Mycobacterium leprae-reactive, CD1-restricted T cell lines: two CD1b restricted and one CD1c restricted. These T cell lines recognize mycobacterial Ags, one of which has not been previously described for CD1-restricted T cells. The response of CD4+ CD1-restricted T cells, unlike MHC class II-restricted T cells, was not inhibited by anti-CD4 mAb, suggesting that the CD4 coreceptor does not impact positive or negative selection of CD1-restricted T cells. The CD4+ CD1-restricted T cell lines produced IFN-gamma and GM-CSF, the Th1 pattern of cytokines required for cell-mediated immunity against intracellular pathogens, but no detectable IL-4. The existence of CD4+ CD1-restricted T cells that produce a Th1 cytokine pattern suggests a contributory role in immunity to mycobacterial infection.</p>},
  year = {2000},
  journal = {Journal of immunology (Baltimore, Md. : 1950)},
  volume = {164},
  pages = {4790-6},
  month = {2000 May 01},
  issn = {0022-1767},
  url = {http://www.jimmunol.org/content/164/9/4790.full.pdf+html},
  doi = {10.4049/jimmunol.164.9.4790},
  language = {eng},
}