@article{18869, keywords = {Antigens, Bacterial, Humans, Interferon-gamma, Interleukin-4, Interleukin-5, leprosy, Mycobacterium leprae, Th1 Cells}, author = {Dockrell H M and Young S K and Britton K and Brennan P J and Rivoire B and Waters M F and Lucas S B and Shahid F and Dojki M and Chiang T J and Ehsan Q and McAdam K P and Hussain R}, title = {Induction of Th1 cytokine responses by mycobacterial antigens in leprosy.}, abstract = {
Twelve mycobacterial antigens were compared for induction of gamma interferon (IFN-gamma) secretion by human blood mononuclear cells of patients with leprosy. Fractionated Mycobacterium leprae antigens containing cell wall proteins or cytosolic and membrane proteins induced good IFN-gamma responses in tuberculoid leprosy patients. Lipoarabinomannan from M. tuberculosis Erdman and M. leprae mycolylarabinogalactan peptidoglycan were the poorest IFN-gamma inducers.
}, year = {1996}, journal = {Infection and immunity}, volume = {64}, pages = {4385-9}, month = {1996 Oct}, issn = {0019-9567}, url = {https://iai.asm.org/content/iai/64/10/4385.full.pdf}, language = {eng}, }