@article{18850,
  keywords = {Animals, Antibody Formation, Armadillos, Humans, leprosy, Receptors, Antigen, T-Cell, gamma-delta, T-Lymphocytes},
  author = {Lathrop G and Scollard D M and Dietrich M},
  title = {Reactivity of a population of armadillo lymphocytes with an antibody to human gamma,delta T-cells.},
  abstract = {<p>Reactivity of lymphocytes from the nine-banded armadillo (Dasypus novemcinctus) was examined by flow cytometry using a panel of 16 commercially available fluorochrome-conjugated monoclonal antibodies raised against human or murine leukocyte antigens. The only reactivity observed was with antibody TCRdelta1, directed against a common determinant on the delta chain of the human gamma,delta T-cell receptor. Using this antibody, a distinct, bright population of lymphocytes was seen in the peripheral blood in all of 47 animals examined, accounting for 2.0-47.1% of lymphocytes (median, 10.6%). The gamma,delta-reactive lymphocyte population comprised a greater percentage of intraepithelial lymphocytes in the small intestine than in the blood; variable percentages of gamma,delta-reactive cells were also observed in the spleen, thymus, lymph nodes, and bone marrow, and in cutaneous lepromas. In armadillos with disseminated Mycobacterium leprae infection, a significantly greater percentage of circulating lymphocytes reacted with the anti-gamma,delta antibody. This is the first described reactivity of armadillo lymphocytes with a monoclonal antibody to a lymphocyte antigen, and it may offer a useful tool in disease models involving the armadillo.</p>},
  year = {1997},
  journal = {Clinical immunology and immunopathology},
  volume = {82},
  pages = {68-72},
  month = {1997 Jan},
  issn = {0090-1229},
  doi = {10.1006/clin.1996.4285},
  language = {eng},
}