@article{18835,
  keywords = {Animals, Cyclosporine, Demyelinating Diseases, Female, Isoantibodies, leprosy, Mice, Mycobacterium leprae, Sciatic Nerve, T-Lymphocytes},
  author = {Shetty V P and Mistry N F and Birdi T J and Antia N H},
  title = {Effect of T-cell depletion on bacterial multiplication and pattern of nerve damage in M. leprae-infected mice.},
  abstract = {<p>Various mechanisms for nerve damage in tuberculoid leprosy have been proposed. A common feature amongst them is the crucial role played by T-cells. Therefore, the present study was designed to determine the role of T-cells in the induction of nerve damage in leprosy using two different protocols for obtaining graded levels of T-cell depletion: (i) Cyclosporine A, for depletion of T-helper cells and (ii) Anti Thy 1.2, for total depletion of T-cells. The findings indicate that the early changes seen in the unmyelinated fibres may not involve T-cells. However, the later stages of nerve damage associated with demyelination are dependent on T-cell responses.</p>},
  year = {1995},
  journal = {Indian journal of leprosy},
  volume = {67},
  pages = {363-74},
  month = {1995 Oct-Dec},
  issn = {0254-9395},
  language = {eng},
}