@article{18724, keywords = {Antibodies, Cells, Cultured, Dinoprostone, Humans, Immune Tolerance, Indomethacin, Interleukin-10, Leprosy, lepromatous, Lymphocyte Activation, Lymphopenia, Monocytes, Th1 Cells}, author = {Misra N and Selvakumar M and Singh S and Bharadwaj M and Ramesh V and Misra R S and Nath I}, title = {Monocyte derived IL 10 and PGE2 are associated with the absence of Th 1 cells and in vitro T cell suppression in lepromatous leprosy.}, abstract = {

Our previous studies had shown that the clinicopathological spectrum in leprosy was associated with discrete T cell subsets in circulation, with tuberculoid patients having antigen-induced Th 1, whereas lepromatous leprosy patients with antigen-specific T cell anergy possessed Th 2 cells. The present study shows that infected monocytes from lepromatous but not tuberculoid leprosy patients released soluble factors (MoF(s)) containing IL-10 and PGE2 which inhibited M. leprae induced in vitro lymphoproliferation of previously sensitised healthy or tuberculoid leprosy subjects. A strong negative correlation was observed between adherent cell derived IL-10 and IL-2 at the level of both the product and cytokine mRNA. Moreover, anti-IL-10 antibodies and indomethacin partially reversed the suppressor effects of MoF(s). Taken together these studies indicate that infected monocytes contribute to the development of T cell anergy by releasing factors that affect regulatory cytokines and T cell subset differentiation in lepromatous leprosy.

}, year = {1995}, journal = {Immunology letters}, volume = {48}, pages = {123-28}, month = {1995 Dec}, issn = {0165-2478}, doi = {10.1016/0165-2478(95)02455-7}, language = {eng}, }