@article{18690, keywords = {Adult, Anti-Bacterial Agents, Humans, Hyperpigmentation, Leprosy, lepromatous, Male, Minocycline}, author = {Fleming C J and Hunt M J and Salisbury E L and McCarthy S W and Barnetson R S}, title = {Minocycline-induced hyperpigmentation in leprosy.}, abstract = {

A 36-year-old man was treated with dapsone, rifampicin and clofazimine for borderline lepromatous leprosy. After 9 months, his leprosy plaques became progressively more red and after 23 months, the clofazimine was stopped and he was given minocycline instead. Six weeks later, he developed blue-black pigmentation in his leprosy lesions. The histology was consistent with minocycline-induced hyperpigmentation. This is the first report of minocycline-induced pigmentation in leprosy. We suggest it is important to consider this side-effect before the administration of minocycline in leprosy, particularly if it is prescribed in place of clofazimine.

}, year = {1996}, journal = {The British journal of dermatology}, volume = {134}, pages = {784-7}, month = {1996 Apr}, issn = {0007-0963}, language = {eng}, }