@article{18687,
  keywords = {Age Distribution, Aged, Alleles, Apolipoproteins E, Female, genotype, Humans, leprosy, Male, Middle Aged},
  author = {Endoh M and Ueki A and Takahashi K and Yamanaka H and Izumi S and Tabira T},
  title = {Significantly increased frequency of the apolipoprotein E epsilon 4 allele in elderly non-demented leprosy patients.},
  abstract = {<p>Apolipoprotein E (apo E) genotypes in 350 leprosy patients were examined and compared with those of 870 age-matched controls. The allelic frequencies of the apo E gene did not differ between demented patients with leprosy and controls. However, the frequency of apo E epsilon 4 allele was significantly higher in non-demented leprosy patients than in controls (P < 0.001). Of special interest is that the prevalence of E3/4 genotype in non-demented leprosy patients increased significantly with age, being 14.1%, 24.4%, and 28.3% in the 60s, 70s, and 80s, respectively (P < 0.05). These data suggest that apo E epsilon 4 is not a risk factor for senile dementia in elderly leprosy patients, and there exist factors to overcome the risk of apo E4 in leprosy patients.</p>},
  year = {1996},
  journal = {Neuroscience letters},
  volume = {207},
  pages = {206-8},
  month = {1996 Apr 05},
  issn = {0304-3940},
  doi = {10.1016/0304-3940(96)12513-1},
  language = {eng},
}