@article{18562,
  keywords = {B-Lymphocytes, Epithelioid Cells, Giant Cells, Langhans, Humans, leprosy, Mycobacterium leprae, Periapical Granuloma, T-Lymphocytes},
  author = {Tani-Ishii N and Osada T and WATANABE Y and Umemoto T},
  title = {Histological findings of human leprosy periapical granulomas.},
  abstract = {<p>Histological analysis of human leprosy periapical granulomas was conducted to study the histological responses to Mycobacterium leprae. Many Langhans-type giant cells and epithelioid cell tubercles were observed, although M. leprae were not detected in leprosy periapical granulomas. Although numerous T- and B-cells were infiltrated in leprosy periapical granuloma, the T-/B-cell ratio of leprosy is not changed to that of periapical granulomas isolated from normal patients. These findings suggested that human leprosy periapical granulomas develop as a result of immunological responses to M. leprae.</p>},
  year = {1996},
  journal = {Journal of endodontics},
  volume = {22},
  pages = {120-2},
  month = {1996 Mar},
  issn = {0099-2399},
  doi = {10.1016/S0099-2399(96)80287-1},
  language = {eng},
}