@article{1853,
  keywords = {Antibodies, Bacterial, Antigens, Bacterial, BCG Vaccine, Corynebacterium pyogenes, Cross Reactions, Humans, Immunoelectrophoresis, Two-Dimensional, leprosy, Listeria monocytogenes, Mycobacterium, Mycobacterium avium, Mycobacterium bovis, Mycobacterium leprae, Mycobacterium phlei, Mycobacterium tuberculosis, Nocardia asteroides},
  author = {Harboe M and Mshana R N and Closs O and Kronvall G and Axelsen N H},
  title = {Cross-reactions between mycobacteria. II. Crossed immunoelectrophoretic analysis of soluble antigens of BCG and comparison with other mycobacteria.},
  abstract = {<p>Cross-reactions between Mycobacterium bovis BCG and various other mycobacteria, Nocardia asteroides, Corynebacterium pyogenes and Listeria monocytogenes were studied by incorporating antibodies against these bacteria in the intermediate gel of a crossed immunoelectrophoretic system with BCG antigen and anti-BCG antibodies. In the BCG reference system forty-four distinct antigenic components were recorded, of which thiryt-three cross-reacted with Mycobacterium tuberculosis, twenty-five with M. avium, twenty-one with M. suvalii, eighteen with M. smegmatis, Fifteen with M. nonchromogenicum, twelve with M. phlei, eight with N. anteroides and two with C. pyogenes, whereas no cross-reaction was detected with L. monocytogenes. The value of the method for characterization of mycobacterial antigens is discussed. A taxonomic system based on this method appears particularly valuable for studies of non-cultivativable mycobacteria such as M. leprae. A majority of twenty-one patients with lepromatous leprosy had anti-BCG antibodies of restricted specificity, affecting only four or five BCG antigens, although one patient had twelve anti-BCG specificities. Most of these antibodies reacted with those BCG antigens that cross-react extensively with other mycobacteria.</p>},
  year = {1979},
  journal = {Scandinavian journal of immunology},
  volume = {9},
  pages = {115-24},
  month = {1979},
  issn = {0300-9475},
  doi = {10.1111/j.1365-3083.1979.tb02713.x},
  language = {eng},
}