@article{18499,
  keywords = {Animals, Female, Fluoroquinolones, leprosy, Mice, Mice, Inbred BALB C, Mycobacterium leprae, Ofloxacin, Quinolones},
  author = {Franzblau S G and Parrilla M L and Chan G P},
  title = {Sparfloxacin is more bactericidal than ofloxacin against Mycobacterium leprae in mice.},
  abstract = {<p>The comparative bactericidal activities of sparfloxacin and ofloxacin against Mycobacterium leprae in mice were determined using the proportional bactericidal test at doses of 12.5 mg/kg-100 mg/kg. Significant bactericidal activity was found at 12.5 mg/kg sparfloxacin and 25 mg/kg ofloxacin. Sparfloxacin was significantly more bactericidal than ofloxacin at all doses, and the results with 25 mg/kg sparfloxacin were nearly identical to those obtained with 100 mg/kg ofloxacin. These results, together with pharmacokinetic and toxicological data in mice and man, suggest that sparfloxacin may have a higher therapeutic index than ofloxacin in leprosy, and that the tentative standard dosage of 200 mg sparfloxacin daily should be appropriate for a clinical trial.</p>
},
  year = {1993},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {61},
  pages = {66-9},
  month = {1993 Mar},
  issn = {0148-916X},
  url = {http://ila.ilsl.br/pdfs/v61n1a11.pdf},
  language = {eng},
}