@article{18498,
  keywords = {Animals, Disease Models, Animal, Female, Immunosuppression, leprosy, Macrophages, Mice, Microscopy, Electron, Nerve Crush, Sciatic Nerve, Silicon Dioxide},
  author = {Shetty V P},
  title = {Animal model to study the mechanism of nerve damage in leprosy--a preliminary report.},
  abstract = {<p>Intraneural injection of 10-20 x 10(6) viable Mycobacterium leprae into the sciatic nerve of normal, unsensitized, Swiss white mice gives rise to a tuberculoid type of granulomatous response in 2 weeks. The same dose of viable M. leprae when injected into the sciatic nerves of unsensitized immunosuppressed mice (T200 x 5R) elicited a macrophage response. When macrophages were systemically immobilized using an intraperitoneal injection of silica quartz dust in normal mice, the lesion produced was of the lepromatous type, suggesting a role for the macrophage in the induction of the tuberculoid type of granulomatous response. In all of these in situ experiments, M. leprae failed to enter the Schwann cells.</p>
},
  year = {1993},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {61},
  pages = {70-5},
  month = {1993 Mar},
  issn = {0148-916X},
  url = {http://ila.ilsl.br/pdfs/v61n1a12.pdf},
  language = {eng},
}