@article{18482,
  keywords = {Bacterial Vaccines, Erythema Nodosum, Humans, Immunotherapy, Leprosy, lepromatous},
  author = {Zaheer S A and Misra R S and Sharma A K and Beena K R and Kar H K and Mukherjee A and Mukherjee R and Walia R and Talwar G P},
  title = {Immunotherapy with Mycobacterium w vaccine decreases the incidence and severity of type 2 (ENL) reactions.},
  abstract = {<p>Immunotherapy with Mycobacterium w (M.w) vaccine was given to 45 patients with multibacillary (MB) leprosy; 41 similarly classified patients served as controls. All patients received standard multidrug therapy (MDT). Incidence, severity and frequency of type 2 (ENL) reactional episodes were monitored in both groups in a follow-up extending up to 4 years. Reactions were seen in fewer vaccinated (10/37) BL and LL patients than in the control group (12/34). A total of 20 episodes were recorded in the vaccine group as against 29 in the controls, 75% of reactions were mild in vaccinated and 51.72% were mild in the control group patients, and 3 patients in the control group had more than 3 reactional episodes. None of the vaccinated patients showed this. No additional incidence of neuritis were seen among vaccinated individuals during reactional episodes.</p>},
  year = {1993},
  journal = {Leprosy review},
  volume = {64},
  pages = {7-14},
  month = {1993 Mar},
  issn = {0305-7518},
  url = {http://leprev.ilsl.br/pdfs/1993/v64n1/pdf/v64n1a02.pdf},
  language = {eng},
}