@article{1827, keywords = {Cytoskeletal Proteins, Dystroglycans, Humans, Laminin, leprosy, Membrane Glycoproteins, Mycobacterium leprae, Myelin Sheath, Peripheral nerves, Peripheral Nervous System Diseases, Protein Isoforms, Protein Structure, Tertiary, Schwann Cells}, author = {Rambukkana A}, title = {How does Mycobacterium leprae target the peripheral nervous system?}, abstract = {

Mycobacterium leprae has the capacity to invade the peripheral nervous system and cause neuropathy. The molecular mechanisms responsible have remained unknown until recently. Identification of the endoneurial laminin-2 isoform and its receptor alpha-dystroglycan as neural targets of M. leprae has not only opened up a new area of scientific inquiry into the pathogenesis of neurological damage in leprosy, but has also revealed unexpected biological properties of these important host molecules.

}, year = {2000}, journal = {Trends in microbiology}, volume = {8}, pages = {23-8}, month = {2000 Jan}, issn = {0966-842X}, doi = {10.1016/s0966-842x(99)01647-9}, language = {eng}, }