@article{18114,
  keywords = {Amino Acids, Animals, Bacterial Vaccines, Immunization, Kidney Cortex, leprosy, Mice, Microvilli, Mycobacterium leprae},
  author = {Kohli M and Kaur S and Ganguly N K and Sharma V K and Chugh K S},
  title = {Transport of amino-acids across renal brush border membrane vesicles in Mycobacterium leprae infected Swiss albino mice--effect of Convit vaccine.},
  abstract = {<p>Brush border membrane vesicles prepared from kidneys of Mycobacterium leprae infected (non-vaccinated) and vaccinated-infected Swiss albino mice were used to assess the effect of Convit's combined vaccine (BCG + M. leprae) on amino acid transport activity across the tubular basement membrane. The protective effect of Convit's vaccine was more pronounced with respect to the uptake of L-alanine than L-aspartate. Uptake of L-lysine showed no significant difference in the different groups. Footpad counts followed characteristic growth curves in the non-vaccinated infected group but showed a lag in the development of peak levels in the vaccinated group. Further Convit's vaccine appeared to have a protective effect on renal impairment in the mouse model of leprosy in the initial stages of infection only, as indicated by the transient reversal of amino acid uptake and a diminution in the footpad counts induced by M. leprae infection. No significant (P > 0.05) protective effect of the vaccine was found in the advanced disease state.</p>},
  year = {1993},
  journal = {Leprosy review},
  volume = {64},
  pages = {316-24},
  month = {1993 Dec},
  issn = {0305-7518},
  url = {http://leprev.ilsl.br/pdfs/1993/v64n4/pdf/v64n4a05.pdf},
  doi = {10.5935/0305-7518.19930036},
  language = {eng},
}