@article{18073,
  keywords = {Diagnosis, Differential, Granuloma, Humans, Immunoenzyme Techniques, Leprosy, Tuberculoid, Mycobacterium leprae, S100 Proteins, Skin, Skin Diseases},
  author = {Singh N and Arora V K and Ramam M and Tickoo S K and Bhatia A},
  title = {An evaluation of the S-100 stain in the histological diagnosis of tuberculoid leprosy and other granulomatous dermatoses.},
  abstract = {<p>Forty biopsies of granulomatous dermatoses, 12 of which were tuberculoid leprosy (TL), were studied for patterns of nerve twig distribution using an immunoperoxidase technique for S-100 protein. Four distinct patterns of nerve twigs were identified: 1) within granulomas, 2) between granulomas, 3) within and between granulomas, and 4) undetectable nerve twigs in an adequate biopsy. Pattern 4 was seen exclusively in TL (p &lt; 0.05). The other patterns occurred in nonleprosy dermatoses as well, suggesting that pattern 4 is the best indicator toward a diagnosis of TL. The granules of mycetoma and Mycobacterium leprae also stained positively with the S-100 stain.</p>
},
  year = {1994},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {62},
  pages = {263-7},
  month = {1994 Jun},
  issn = {0148-916X},
  url = {http://ila.ilsl.br/pdfs/v62n2a09.pdf},
  language = {eng},
}