@article{18064,
  keywords = {Amino Acid Sequence, Base Sequence, Humans, Molecular Sequence Data, Receptors, Antigen, T-Cell, gamma-delta, Sarcoidosis, T-Lymphocytes},
  author = {Tamura N and Suzuki K and YAMAMOTO T and Kira S},
  title = {[The gamma delta T-cell receptors in sarcoidosis].},
  abstract = {<p>T-cells recognize specific antigen (s) through the T-cell antigen receptors (TCR). gamma delta T-cells compose a minor population of the peripheral blood lymphocytes (PBL). These lymphocytes play a central role in recognizing the mycobacterial antigens and granuloma formation in tuberculosis and leprosy. Significant increase of gamma delta T-cells in PBL is observed in a subgroup of sarcoidosis. The majority of gamma delta T-cells showed V gamma 9/V delta 2 recombination, which is common in normal blood. To evaluate the clonality of the increased gamma delta T-cells in PBL, several V gamma 9 and V delta 2 cDNA clones were established. Analysis of V-J junctional sequences of V gamma 9 clones revealed oligoclonal expansion in some cases. Most of V delta 2 clones showed unique sequences. Although no clonal expansion of gamma delta T-cells were observed, TCR-gamma chain might recognize limited numbers of putative antigens in sarcoidosis.</p>},
  year = {1994},
  journal = {Nihon rinsho. Japanese journal of clinical medicine},
  volume = {52},
  pages = {1473-9},
  month = {1994 Jun},
  issn = {0047-1852},
  language = {jpn},
}