@article{17671,
  keywords = {Administration, Oral, Animals, Dapsone, Drug Administration Schedule, Drug Therapy, Combination, Female, Fluoroquinolones, Leprostatic Agents, leprosy, Mice, Mice, Inbred BALB C, Mice, Nude, Mycobacterium leprae, Quinolones, Rifamycins},
  author = {Gidoh M and Matsuki G and Tsutsumi S and HIDAKA T and Nakamura S},
  title = {Inhibition of the multiplication of Mycobacterium leprae in nude mice by intermittent administration of a new rifamycin derivative, 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin (KRM-1648) combined with sparfloxacin.},
  abstract = {<p>Inhibition of the multiplication of Mycobacterium leprae in the footpads of nude mice by the oral administration of sparfloxacin, a new quinolone, and 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin (KRM-1648), selected from a series of newly synthesized benzoxazinorifamycins, was studied. When the 2 drugs were administered alternately at intervals of 3 or 4 days, (i.e., each drug was administered once weekly), or simultaneously once weekly, between 3 and 5 months after inoculation of nude mice with M. leprae, 10 mg sparfloxacin and 0.6 mg KRM-1648 per kg bodyweight were sufficient to prevent multiplication of the organisms. Only partial inhibition of multiplication was achieved by alternate administration of 5 mg sparfloxacin and 0.3 mg KRM-1648 per kg, as was the case for 20 mg sparfloxacin per kg or 1 mg KRM-1648, each drug administered alone once weekly. The addition to these 2 drugs of dapsone, administered in the diet in a concentration of 0.001 g per 100 g, enhanced their effect. The potential usefulness of multidrug regimens including these compounds is considered.</p>},
  year = {1995},
  journal = {Leprosy review},
  volume = {66},
  pages = {39-47},
  month = {1995 Mar},
  issn = {0305-7518},
  url = {http://leprev.ilsl.br/pdfs/1995/v66n1/pdf/v66n1a06.pdf},
  doi = {10.5935/0305-7518.19950006},
  language = {eng},
}