@article{17653,
  keywords = {Acute Kidney Injury, Aged, Chemical and Drug Induced Liver Injury, Dapsone, Diagnosis, Differential, Drug Therapy, Combination, Fatal Outcome, Humans, Kidney, leprosy, Liver, Male, Myocarditis, Myocardium, Nephritis, Interstitial, Rifampin},
  author = {Lau G},
  title = {A fatal case of drug-induced multi-organ damage in a patient with Hansen's disease: dapsone syndrome or rifampicin toxicity?},
  abstract = {<p>An elderly patient with borderline tuberculoid Hansen's disease (leprosy) developed the diaminodiphenylsulphone syndrome after approximately 8 weeks of multi-drug therapy comprising dapsone and rifampicin. Postmortem histological examination, following autopsy, demonstrated features consistent with drug-induced hepatitis, tubulo-interstitial nephritis and myocarditis. Although these could have been engendered by dapsone toxicity, it was thought that a concommitant adverse reaction to rifampicin, which is known to be hepatotoxic, nephrotoxic and possibly capable of predisposing to the dapsone syndrome, could not be excluded.</p>},
  year = {1995},
  journal = {Forensic science international},
  volume = {73},
  pages = {109-15},
  month = {1995 May 22},
  issn = {0379-0738},
  doi = {10.1016/0379-0738(95)01719-y},
  language = {eng},
}