@article{17497,
  keywords = {Animals, Anti-Infective Agents, Clarithromycin, Dapsone, Drug Therapy, Combination, Female, Fluoroquinolones, leprosy, Mice, Mice, Inbred BALB C, Minocycline, Quinolones, Rifampin},
  author = {Gelber R H and Siu P and Tsang M and Richard V and Chehl S K and Murray L P},
  title = {Activity of combinations of dapsone, rifampin, minocycline, clarithromycin, and sparfloxacin against M. leprae-infected mice.},
  abstract = {<p>In these studies we evaluated the activity of low levels of five antimicrobials against Mycobacterium leprae-infected mice when administered singly and in all possible two- and three-drug combinations. Antibiotics studied were: dapsone (D) 0.0001% in the diet, rifampin (R) 20 mg/kg by gavage once monthly, minocycline (M) 0.004% in the diet, clarithromycin (C) 0.001% in the diet, and sparfloxacin (S) 5 mg/kg by gavage five times weekly. Singly each agent was found bacteriostatic (D + R) or partially bactericidal (M, C, and S) but not fully bactericidal. All 10 two-drug regimens were found at least bacteriostatic, 2 being "partially bactericidal" and 4 being "fully bactericidal." Of the 10 three-drug regimens, 9 were found "fully bactericidal" and the other "partially bactericidal." We conclude that combinations of antibiotics active against M. leprae are generally additive in combination.</p>
},
  year = {1995},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {63},
  pages = {259-64},
  month = {1995 Jun},
  issn = {0148-916X},
  url = {http://ila.ilsl.br/pdfs/v63n2a08.pdf},
  language = {eng},
}