@article{17488,
  keywords = {Animals, Antigens, Bacterial, Cercocebus atys, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Glycolipids, Immunoglobulin G, Immunoglobulin M, leprosy, Lipopolysaccharides, Longitudinal studies, Mycobacterium leprae},
  author = {Gormus B J and Xu K and Cho S N and Baskin G B and Bohm R P and Martin L N and Blanchard J L and Mack P A and Ratterree M S and Meyers W M},
  title = {Experimental leprosy in monkeys. II. Longitudinal serological observations in sooty mangabey monkeys.},
  abstract = {<p>In this study, 11 SMM were grouped and inoculated with differing doses of SMM-origin Mycobacterium leprae (ML) between 4.5 x 10(8) and 1 x 10(9) by either combined IV/IC routes or by IV or IC route alone. The combined route was the most effective in eliciting progressive, disseminated LL leprosy. In all, 6 of 7 SMM inoculated by the combined routes developed leprosy requiring treatment at some point. Only 1 of 4 inoculated by a single route developed persisting leprosy requiring chemotherapy. Either no disease or spontaneous regression of initial disease occurred in the other 3 animals inoculated by a single route. Doses in excess of 1 x 10(9) ML were more effective than lesser doses. An association was observed between the development of IgG anti-PGL-I ELISA OD values and resistance to leprosy and between IgM anti-PGL-I and leprosy progression or susceptibility. Serum PGL-I antigen levels, determined by dot ELISA, paralleled disease severity longitudinally. High positive OD values of anti-LAM IgG prior to ML inoculation were observed in the majority of leprosy-susceptible SMM in contrast to negative levels in more resistant animals. Anti-LAM IgG OD values exceeded the positive cut-off point after inoculation in 5 of 11 SMM; 3 of these 5 had concurrent detectable serum levels of PGL-I antigen.</p>},
  year = {1995},
  journal = {Leprosy review},
  volume = {66},
  pages = {105-25},
  month = {1995 Jun},
  issn = {0305-7518},
  url = {http://leprev.ilsl.br/pdfs/1995/v66n2/pdf/v66n2a03.pdf},
  doi = {10.5935/0305-7518.19950013},
  language = {eng},
}