@article{17374,
  keywords = {Antigen Presentation, Antigen-Presenting Cells, Antigens, CD, Antigens, CD1, Carbohydrate Conformation, Carbohydrate Sequence, Cell Line, Humans, Interferon-gamma, Interleukin-4, leprosy, Lipopolysaccharides, Lymphocyte Activation, Molecular Sequence Data, Mycobacterium leprae, Phosphatidylinositols, Receptors, Antigen, T-Cell, alpha-beta, Species Specificity, T-Lymphocytes, Cytotoxic},
  author = {Sieling P A and Chatterjee D and Porcelli S A and Prigozy T I and Mazzaccaro R J and Soriano T and Bloom B R and Brenner M B and Kronenberg M and Brennan P J},
  title = {CD1-restricted T cell recognition of microbial lipoglycan antigens.},
  abstract = {<p>It has long been the paradigm that T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be presented to T cells by human CD1b molecules, which are not encoded by the MHC. A major class of microbial antigens associated with pathogenicity are lipoglycans. It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes. Presentation of these lipoglycan antigens required internalization and endosomal acidification. The T cell recognition required mannosides with alpha(1-->2) linkages and a phosphotidylinositol unit. T cells activated by LAM produced interferon gamma and were cytolytic. Thus, an important class of microbial molecules, the lipoglycans, is a part of the universe of foreign antigens recognized by human T cells.</p>},
  year = {1995},
  journal = {Science (New York, N.Y.)},
  volume = {269},
  pages = {227-30},
  month = {1995 Jul 14},
  issn = {0036-8075},
  doi = {10.1126/science.7542404},
  language = {eng},
}